helixstreet.com is the operating company of the Helixstreet group — uniting autonomous genomic artificial intelligence (helixstreet.ai), decentralized life-sciences settlement and provenance (helixstreet.io), and Swiss protocol governance (helixstreet.foundation).
Helixstreet builds one product: consent and provenance infrastructure for genomic data. The chain records who consented to what; the validators and public RPC keep it running; the agent fleet, digital twins and HelixGroups are how data gets in. Helixstreet is self-funded and not looking for investors.
Winner of Best Architectural Design in Google's All Things Agentic Hackathon ($180,000 USD prize pool · 12,260 participants · 78 Google & GDE judges) and member of the NVIDIA Inception program since 2019 (renewed 2026).
Track: The Fortified Enterprise Fleet. Competing in one of the largest AI agent hackathons globally ($180,000 USD in prizes across 12,260 participants evaluated by 78 Google & GDE judges), Helixstreet won Best Architectural Design. Drop a raw sequencing file (BAM) into a Cloud Storage bucket and walk away — no chat loop, no clicks, no waiting human. Eventarc wakes a governed five-agent fleet on Google ADK: a Gemma 4 31B intake gatekeeper screens with Model Armor and scrubs PII via Cloud DLP, Gemini 3.5 Flash dispatches Google DeepVariant on Cloud Batch, goes dormant across the compute gap, wakes itself when the VCF lands, cross-references 1000 Genomes in BigQuery and CPIC pharmacogenomics, and seals a tamper-evident digital twin in ~9 minutes.
helixstreet_intake (Gemma 4 31B) + 4 Gemini 3.5 Flash specialists with live OpenTelemetry / Cloud Trace spans.
CYP2C19 *2/*2 clopidogrel alert with Europe PMC citations.
COMMITMENT_ANCHORED) + SHA-256 audit chain verified on every refresh.
Nemotron-3 Nano 30B / Super 120B) and NVIDIA Clara Parabricks for multi-cloud sovereign deployments.
Our long-horizon mission is to advance all forms of life and health, enhance human biology, and cryptographically preserve the genomic blueprints of Earth's species as humanity expands toward Mars. By sealing genomes in salted Merkle trees and SHA-256 ledgers, altering a single base pair changes the root hash — giving us mathematical, tamper-evident proof of authentic, original life. NO LIMITS AT THE FRONTIER OF AI, GENOMICS & PROTEOMICS.
We are measured by systems in production: winner of Best Architectural Design in Google's All Things Agentic Hackathon ($180,000 prize pool · 12,260 participants · 78 judges), Polkadot validators consistently graded A+ with top-tier slot inclusion and era performance, and public RPC nodes delivering 100.00% availability at the lowest latencies on the network. WE DELIVER REAL RESULTS — NOT LINKEDIN AND TWITTER NOISE. WE DELIVER.
A focused, senior engineering core amplified by a governed fleet of autonomous AI agents — orchestrated during the Google hackathon and in daily engineering with our own multi-agent orchestrator uta (unleashtheagents.ai) ↗. No bloated committees, no performative roadmaps, and zero organizational drag — WE DO NOT OVERTHINK. WE JUST DO.
Helixstreet keeps the structure plain: one operating company that owns the product, and one Swiss non-profit foundation that runs the public validators and stewards the open protocol. Self-funded, not looking for investors, no token.
Six production capabilities uniting deep-learning bioinformatics, clinical pharmacogenomics, and cryptographic data sovereignty.
High-fidelity long-read sequencing (PacBio HiFi & Oxford Nanopore) combined with de novo assembly and Google DeepVariant. We capture structural variants, novel insertions, and rare mutations that standard reference-only pipelines miss.
Enterprise licensing of our award-winning five-agent Google ADK pipeline (Gemma 4 31B + Vertex AI Gemini 3.5 Flash & 2.5 Pro), deployed directly inside hospital, biobank, or pharmaceutical Google Cloud perimeters.
Machine-learning classification of genomic and proteomic signatures into HelixGroups — enabling pharmaceutical companies to certify medications against specific genetic clusters, accelerate clinical trials, and eliminate trial-and-error prescriptions.
Salted SHA-256 Merkle trees and hash-chained ledgers seal human and planetary genomes against silent tampering. Altering a single nucleotide changes the root hash — proving authentic, original biological life on Earth and for future habitats on Mars.
AI-driven digital replicas of your biological self (app.helixstreet.io) that integrate genomic, phenotypic, and pharmacogenomic data inside a user-owned cloud vault — evolving continuously as biomedical science advances.
Direct architectural engagements with pharmaceutical leaders globally on where AI agents, zero-knowledge eligibility proofs, and on-chain provenance solve regulatory and clinical-trial bottlenecks.
Standard healthcare prescribes for the statistical average and reacts only after disease manifests. Yet patients naturally belong to multiple overlapping genetic clusters simultaneously. Our machine-learning and large-language-model pipelines analyze high-fidelity, de novo assembled HiFi DNA and proteomic profiles to classify individuals into HelixGroups — capturing structural variants, rare insertions, and non-linear multi-gene interactions that govern drug metabolism, efficacy, and adverse-reaction risk.
Pharmaceutical sponsors can certify compounds against specific HelixGroups and recruit clinical-trial cohorts using zero-knowledge eligibility proofs on helixstreet.io — proving that participants match exact genetic inclusion criteria without ever exposing raw patient DNA.
Helixstreet is not looking for investors. There is no token, no presale and no planned listing. The structure is deliberately plain so every option stays open later.
A Polkadot SDK chain that records consent receipts, eligibility proofs and provenance for genomic and proteomic datasets — never the sequences themselves. Everything else we build feeds it.
helixstreet.com is the operating company: it owns the product, the IP and the enterprise contracts. helixstreet.foundation is a Swiss non-profit that runs the public validators and stewards the open protocol.
We are not looking for investors and we are not planning a public listing. Validator nominations earn standard Polkadot staking rewards and create no claim on Helixstreet.
No offices, no committees. A governed fleet of autonomous agents does the engineering, analysis, and operations; a small human core sets direction and stays accountable for every release.
Autonomous agents plan, write, test, and ship code across the Google Cloud ADK fleet, the NVIDIA & Nebius stack, and the Polkadot infrastructure — orchestrated the same way they were during the Google hackathon.
The Helixstreet Foundation stewards protocol governance and operates our A+ Polkadot validators and 100.00% uptime RPC infrastructure.
helixstreet.foundation/1 & /2 validatorsExecutive advisory for pharmaceutical and biotech partners on where AI agents, zero-knowledge eligibility proofs, and on-chain provenance solve regulatory and data-governance problems.
helixstreet.foundation validators on Polkadot earns standard staking rewards at 0% commission and creates no claim on Helixstreet. View validator & nomination details ↗How we built an event-driven, zero-chat-loop autonomous genomic fleet on Google ADK, Gemini 3.5 Flash, Gemma 4, and DeepVariant — and the five production bugs that shaped it.
Updated for Polkadot 2.0. What is actually involved in stitching consent, identity, storage, and IP-NFT settlement across chains via XCM v5.
Twins, theft, family leakage, irrevocability. The rigorous case against using genomes as a Sybil-resistance primitive, and how ZK eligibility proofs solve the real problem.